Preparation and characterization of the second near-infrared window fluorescent/photoacoustic imaging liposomes
10.11665/j.issn.1000-5048.20190508
- VernacularTitle:近红外二区荧光/光声双模态成像脂质体的制备与表征
- Author:
Yang LIU
1
;
Zian WANG
;
Yifei JIANG
;
Min JI
;
Peng WANG
Author Information
1. 东南大学生物科学与医学工程学院
- Publication Type:Journal Article
- Keywords:
fluorescence;
enhancement;
photoacoustic;
tumor;
photothermal therapy
- From:
Journal of China Pharmaceutical University
2019;50(5):560-564
- CountryChina
- Language:Chinese
-
Abstract:
The second near-infrared window(NIR-II)fluorescent dye IR-1061 has the disadvantage of poorwater solubility and low quantum yield, which limits its application in biomedicine. We used liposomes as the carrier to increase their water solubility, and co-loaded a near-infrared region(NIR-I)fluorescent dye IR-780 into liposomes to enhance the fluorescence intensity of IR-1061 in NIR-II. Results showed that the liposomes exhibited significantly enhanced characteristic fluorescence under 980 nm laser irradiation. In addition, particle size, appearance, photothermal conversion efficiency, photoacoustic performance and cytotoxicity of liposomes were examined. This study showed that these combined liposomes exhibited potential as a NIR-II fluorescence/photoacoustic bimodal imaging system for the diagnosis and guidance of tumor photothermal therapy.
