Research progress of PARP-1 inhibitors in combination with other drugs to overcome drug resistance
10.11665/j.issn.1000-5048.20190503
- VernacularTitle:PARP-1抑制剂与其他药物联用克服耐药性的研究进展
- Author:
Jinyu SHI
1
;
Ying BAI
;
Kewen PENG
;
Wenhui ZHANG
;
Qihua ZHU
;
Yungen XU
Author Information
1. 中国药科大学药物化学系
- Publication Type:Journal Article
- Keywords:
poly(ADP-ribose)polymerase-1;
PARP-1 inhibitors;
antitumor;
drug resistance;
drug combination
- From:
Journal of China Pharmaceutical University
2019;50(5):523-530
- CountryChina
- Language:Chinese
-
Abstract:
Poly(ADP-ribose)polymerase-1(PARP-1)plays a vital role in the regulation of DNA repair and apoptosis. Breakthrough has been made in the treatment of cancer with PARP-1 inhibitors, but the emergence of drug resistance has limited its further application in clinic. This paper reviews advances in the research on PARP-1 inhibitors combined with other drugs to overcome drug resistance, highlights and evaluates the existing drug combination strategies and their therapeutic effects in clinical practice. It is proposed that the development of dual-target or multi-target drugs will become a promising approach to overcome the resistance of PARP-1 inhibitors and broaden their indications.
