Advances in core protein allosteric modulators
10.11665/j.issn.1000-5048.20190502
- VernacularTitle:核心蛋白变构调节剂的研究进展
- Author:
Qianqian GAO
1
;
Kailin HAN
;
Guocheng WANG
;
Tao LU
Author Information
1. 天士力控股集团有限公司研究院化学药品开发中心；中国药科大学理学院
- Publication Type:Journal Article
- Keywords:
hepatitis B;
core protein;
core protein allosteric modulators;
new drug development;
progress
- From:
Journal of China Pharmaceutical University
2019;50(5):516-522
- CountryChina
- Language:Chinese
-
Abstract:
The core protein allosteric modulator targets the core protein and inhibits hepatitis B virus(HBV)replication by regulating the formation of covalently closed circular DNA(cccDNA), which is expected to completely cure hepatitis B and overcome the drug resistance of nucleoside drugs. This paper reviews the replication process of HBV, the function of core proteins, the mechanism, classification and research progress of core protein allosteric modulators, lists 12 drugs, and summarizes their mechanisms, categories, chemical structures, safety, anti-HBV effects, combined drug use, etc. In addition, the advantages and problems of core protein allosteric modulators are discussed to provide references for the development of new anti-HBV drugs.
