Effect of rectal administration of hydroxycodone hydrochloride sustained-release tablets on cancer pain
10.3760/cma.j.issn.1008-6706.2018.17.005
- VernacularTitle: 盐酸羟考酮缓释片直肠给药治疗癌性疼痛的效果观察
- Author:
Weixian CHEN
1
Author Information
1. Department of Oncology, the Second People's Hospital of Jiande, Jiande, Zhejiang 311604, China
- Publication Type:Journal Article
- Keywords:
Oxycodone hydrochloride prolonged-release tablets;
Administration, rectal;
Cancer pain
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(17):2193-2196
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the efficacy and adverse effect of oxycodone hydrochloride prolonged-release tablets rectal administration in the treatment of cancer pain.
Methods:From July 2016 to July 2017, eighty patients with cancer pain in the Second People's Hospital of Jiandewere selected in the research.The patients were randomly divided into control group and observation group according to the digital table, with 40 cases in each group.The two groups were treated with oxycodone hydrochloride prolonged-release tablets, the control group was treated by oral administration, while the observation group was treated by rectal administration.At different time points after administration, the degree of pain(NRS) score, pain remission rate, quality of life before and after treatment, the incidence of adverse reactions were compared between the two groups.
Results:After the administration of 1 h, 3 h, the NRS scores of the observation group were (4.49±1.25)points, (3.80±1.13)points, which were lower than those of the control group[(5.56±1.42)points, (5.04±1.10)points], the differences were statistically significant(t=3.58, 4.97, all P<0.05). After administration of 1 d, 1 week and 2 weeks, the NRS scores between the two groups showed no statistically significant difference(P>0.05). The pain relief rate of the observation group was 92.50%, which was significantly higher than 75.00% of the control group, the difference was statistically significant(χ2=4.50, P<0.05). The indicators of quality of life in the observation group were significantly better than those in the control group, the differences were statistically significant(t=2.09, 2.20, 3.16, 3.28, all P<0.05). The incidence rate of adverse reaction of the observation group was 12.50%, which of the control group was 10.00%, there was no statistically significant difference between the two groups(P>0.05).
Conclusion:The analgesia effect of oxycodone hydrochloride prolonged-release tablets by rectal administration is similar with oral administration for cancer pain patients, and has less adverse reaction, high safety, and it is worthy of popularization and application.
