Clinical research of transcatheter arterial chemoembolization combined with three dimensional conformal radiotherapy and hyperthermia for primary hepatic carcinoma
10.3760/cma.j.issn.1008-6706.2018.17.004
- VernacularTitle: 介入治疗联合放疗和热疗用于中晚期肝癌的临床研究
- Author:
Shurui LU
1
;
Jundong CAI
1
;
Guijie LIANG
1
;
Jing LIU
2
;
Zhenya WANG
1
Author Information
1. Department of Oncology, the Third Hospital of Chengde, Chengde, Hebei 067000, China
2. Nursing Department, Maternity and Child Care Centers of Chengde, Chengde, Hebei 067000, China
- Publication Type:Journal Article
- Keywords:
Liver neoplasms;
Transcatheter arterial chemoembolization;
Radiotherapy;
Hyperthermia
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(17):2189-2192,c17-1
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of transcatheter arterial chemoembolization(TACE) combined with three dimensional conformal radiotherapy(3-DCRT) and hyperthermia on inoperable primary hepatic carcinoma.
Methods:This study retrospectively analyzed 96 patients with hepatic carcinoma in the Third Hospital of Chengde between 2014 and 2017 who received TACE or combined therapy (TACE combined with 3-DCRT and hyperthermia). Kaplan-Meier curve was used to compare the overall survival(OS) of the two groups.
Results:There were 50 cases in the combined therapy group, 46 cases in the TACE group.The effective rate of the combined therapy group was 76.1%, and that of TACE group was 45.6%, the difference was statistically significant(P=0.028). The overall 6-, 12- and 18-month survival rates of the combined therapy group were 98.0%, 89.9% and 63.1%, respectively, which in the TACE group were 91.3%, 67.3% and 46.8%, respectively, the difference between the two groups was significant(χ2=7.836, P=0.005). The incidence of adverse effect of the combined therapy group was low, only 2 patients(4.0%) developed radiation-induced liver disease(RILD), and the liver function recovered to the normal level after 8 weeks.
Conclusion:TACE combined with 3-DCRT and hyperthermia is more effective than TACE alone for inoperable primary hepatic carcinoma, and with a low incidence of adverse effect.
