The Effects of Intravesical Oxybutynin Chloride in Spinal Cord Injury Patients Who Had Clinical Problems on Oral Medication.
- Author:
In Eui LEE
1
;
Ho Cheol CHOI
;
Won Hee PARK
Author Information
1. Department of Urology, Korea Veterans Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Spinal cord injury;
Neurogenic bladder;
Intravesical instillation;
Oxybutynin chloride
- MeSH:
Administration, Intravesical;
Humans;
Spinal Cord Injuries*;
Spinal Cord*;
Tablets;
Urinary Bladder;
Urinary Bladder, Neurogenic;
Urodynamics
- From:Korean Journal of Urology
1995;36(3):306-310
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Oxybutynin chloride was administered intravesically in 7 spinal cord injury patients with persistent incontinence and frequent side effects on oral medication. Five mg tablets were dissolved in 20 ml normal saline, and the solution was instilled twice daily and retained for 30 minutes. All patients reported subjective improvement following treatment and all became totally continent. No side effects were observed. In urodynamic study mean bladder capacity increased from 250 to 400ml(P = 0.005) and mean maximum filling pressure decreased from 25 to 18cmH2O (P = 0.283). In conclusion treatment with intravesical oxybutynin chloride can be effective in spinal cord injury patients who either are unresponsive to or have intolerable side effects on oral medication.
