Analysis of related factors of radiation induced lung injury after radiotherapy in the elderly patients with advance esophageal cancer
10.3760/cma.j.issn.1008-6706.2018.11.025
- VernacularTitle: 老年人局部晚期食管癌放疗所致放射性肺损伤的相关因素分析
- Author:
Maoyu WANG
1
;
Sha SHA
;
Peng GAO
;
Fuyu LUAN
Author Information
1. Department of Radiotherapy, Jiaozhou Central Hospital of Qingdao, Qingdao, Shandong 266300, China
- Publication Type:Journal Article
- Keywords:
Esophageal tumor;
Radiotherapy, conformal;
Lung injury;
Aged
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(11):1456-1459
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the related factors of radiation induced lung injury(RILI) after three-dimensional conformal radiotherapy(3D-CRT) in the elderly patients with advance esophageal cancer, thus to provide reference for radiotherapy planning.
Methods:The clinical data and physical parameters of 72 elderly patients with advance esophageal cancer were analyzed, including gender, age, performance status scoring, smoking history, tumor location, T staging, underlying disease of the lung, radiation dose, the whole lung accepted 5 Gy exposure volume(V5), V10, V15, V20, V25, V30, V40 and mean lung dose(MLD).
Results:Among 72 patients, 15 cases developed RILI.It was revealed by univariate analysis that there were statistically significant differences in advanced age, underlying disease of the lung, V5, V10, V15, V20, V25, MLD with RILI(χ2=5.098, P=0.026; χ2=3.598, P=0.030; t=3.854, P=0.034; t=4.901, P=0.022, t=4.638, P=0.029, t=5.122, P=0.015, t=3.652, P=0.041, t=5.760, P=0.010).
Conclusion:It should be payed more attention to factors such as advanced age, underlying disease of the lung, V5, V10, V15, V20, V25 and MLD when elderly patients with advance esophageal cancer patients were treated with 3D-CRT in order to prevent and decrease the risks of RILI.
