Effect of colchicine in the treatment of elderly patients with gouty arthritis and its influence on ESR, CRP and UA
10.3760/cma.j.issn.1008-6706.2018.11.019
- VernacularTitle: 秋水仙碱治疗痛风性关节炎的疗效及对患者红细胞沉降率、C反应蛋白、尿酸水平的影响
- Author:
Jiaying WU
1
;
Yingjie GU
2
Author Information
1. Department of Outpatient Pharmacy, the Traditional Chinese Medicine Hospital of Ningbo, Ningbo, Zhejiang 315010, China
2. Department of Internal Medicine, the Traditional Chinese Medicine Hospital of Ningbo, Ningbo, Zhejiang 315010, China
- Publication Type:Journal Article
- Keywords:
Arthritis, gouty;
Colchicine tablets;
Uric acid;
Blood sedimentation;
C-reactive protein
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(11):1432-1435
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical efficacy of colchicine tablets in the treatment of patients with gouty arthritis, and to observe the effect of colchicine tablets on erythrocyte sedimentation rate(ESR), C-reactive protein (CRP) and uric acid (UA).
Methods:From March 2016 to March 2017, 70 patients with gouty arthritis in our hospital were randomly divided into control group and observation group according to the random number table method.The control group was treated with celecoxib capsules 0.2g, 2 times a day.The observation group was treated with colchicine tablets 0.5mg three times daily, celecoxib capsules 0.2g, 2 times a day.The visual analogue scale (VAS) was used to evaluate the degree of joint pain in two groups.The Likert scale was used to evaluate the swelling of the two groups before and after treatment.The pain relief time was recorded in both two groups.The ESR, CRP and UA were measured before and after treatment.The clinical effects and adverse reactions in the two groups were analyzed.
Results:After treatment, the VAS score of the observation group was (2.04±0.52)points, which was significantly lower than (3.53±1.22)points of the control group(t=6.64, P=0.00). The joint swelling score of observation group after treatment was (0.62±0.24) points, which was significantly lower than (1.21±0.33)points of the control group(t=8.55, P=0.00). After treatment, the VAS score and joint swelling score in the two groups were significantly lower than those before treatment (all P<0.05). The pain relief time of the observation group was significantly shorter than that of the control group [(1.36±0.47)d vs.(1.79±0.63)d, t=3.23, P=0.00]. After treatment, the ESR, CRP and UA levels of the observation group were (12.65±3.17)mm/h, (12.14±2.27)mg/L, (417.82±55.88)μmol/L, respectively, which were significantly lower than those of the control group [(14.77±4.22)mm/h, (14.69±3.16)mg/L, (458.93±62.74)μmol/L, t=2.37, 3.87, 2.37, P=0.02, 0.00, 0.00]. After treatment, the ESR, CRP and UA levels of the two groups were significantly lower than those before treatment (all P<0.05). The total effective rate of the observation group was 80.00%, which was obviously higher than 57.14% of the control group(χ2=7.55, P=0.02). The incidence rate of adverse reaction of the observation group was 8.57%, which of the control group was 5.71%, the difference was not statistically significant (χ2=0.21, P=0.64).
Conclusion:Colchicine tablets combined with celecoxib capsules in the treatment of patients with gouty arthritis can reduce ESR, CRP and UA levels, improve the degree of pain and joint swelling, and will not increase the adverse reactions.
