Ketorolac tromethamine combiend with sufentanil on median effective dose of analgesia after cesarean delivery
10.3760/cma.j.issn.1008-6706.2018.11.007
- VernacularTitle: 酮咯酸氨丁三醇联合舒芬太尼用于剖宫产术后镇痛的半数有效量研究
- Author:
Yuee LIU
1
;
Jun'er GUO
;
Tao CHEN
Author Information
1. Department of Anesthesiology, Fenyang Hospital of Shanxi Province, Lyuliang, Shanxi 032200, China
- Publication Type:Journal Article
- Keywords:
Dose-response relationship, drug;
Cesarean section;
Ketorolac tromethamine;
Sufentanil
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(11):1383-1386
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the median effective dose of ketorolac tromethamine combined with different doses of sufentanil.
Methods:From February 2016 to June 2017, 60 cases of cesarean section were selected.According to the random number table method, they were divided into two groups, with 30 cases in each group.Group I was treated with sufentanil 0.75μg/kg+ dexmedetomidine 200μg, while sufentanil 1μg/kg+ dexmedetomidine 200μg was used in group II.The first two groups were added to pump 150 mg ketorolac tromethamine, gradually increased or decreased in accordance with 30mg effect according to satisfaction or dissatisfaction.The median effective dose of ketorolac tromethamine in the two groups was analyzed.
Results:After operation, the systolic blood pressure[(112.5±9.6)mmHg vs.(122.5±8.4)mmHg, (114.2±9.9)mmHg vs.(124.1±8.2)mmHg]and heart rate[(80.6±13.5)times/min vs.(90.5±16.5)times/min, (77.6±15.5)times/min vs.(88.2±18.8)times/min]in the two groups were significantly lower than those before operation (t=4.587, 5.248, 4.214, 3.983, all P<0.05). The VSA scores of the two groups decreased significantly[(6.8±2.4)points, (3.4±1.4)points, (2.1±0.9)points, (6.9±3.1)points, (3.5±1.7)points, (2.2±0.7)points], the difference was statistically significant at different time points (F=4.977, P<0.05). ED50 and 95% confidence interval of ketorolac tromethamine in the group I was 91.75mg, 78.69-106.98mg, which in the group II was 72.44mg, 60.40-86.90mg.
Conclusion:Ketorolac tromethamine combined with sufentanil has good analgesia effect, less adverse reaction.When sufentanil was given at 0.75 and 1μg/kg, the ED50 of ketorolac tromethamine were 91.75mg and 72.44mg.
