Study on airway inflammation in patients with occupational pulmonary thesaurosis induced by iron
10.3760/cma.j.issn.1001-9391.2018.11.015
- VernacularTitle: 金属粉尘肺沉着病患者气道炎症的变化
- Author:
Wenlan YANG
1
;
Daoyuan SUN
;
Ling MAO
;
Shaowei ZHOU
;
Beilan GAO
Author Information
1. Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China
- Publication Type:Case Reports
- Keywords:
Occupational pulmonary thesaurosis;
Iron dust;
Induced sputum;
Airway inflammation
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2018;36(11):852-854
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the airway inflammation feature difference in the patients with occupational pulmonary thesaurosis induced by iron.
Methods:Induced sputum samples were obtained from 20 healthy men, 20 patients with stable asthma, 25 patients with occupational pulmonary thesaurosis induced by iron. Differential cell counts in induced sputum were examined. The levels of supernatant IL-8 were measured by ELISA.
Results:The pulmonary function result was normal in the patients with pulmonary thesaurosis., their FVC (4.1±1.2) L was similar to FVC (4.3±0.9) L in mal group; but their FEV1.0 (2.9±0.9) L、FEV1/FVC (71.9%±5.4%) were lower than normal group’s FEV1.0 (3.2±0.7 L) 、FEV1.0/FVC (79.2%±9.9%) , and were hirher than asthma group’s FEV1 (2.5±0.8) L and FEV1.0/FVC (68.7%±6.1%) . In induced sputum, macrophages percentage in patients with pulmonary thesaurosis (54.3%±9.7%) was higher than asthma group and normal group (48.4±6.4, 51.9±7.3, P<0.05) , neutrophils percentage in patients with pulmonary thesaurosis group (43.9%±7.6%) was higher than asthma group and normal group (41.3%±7.1%, 39.8%±6.9%, P<0.05) , eosinophils percentage in patients with pulmonary thesaurosis group (0.3%±0.1%) was lower than asthma group (2.8±0.3, P<0.05) , lymphocytes percentage in patients with pulmonary thesaurosis group (2.0%±0.4%) was lower than asthma group (4.7±0.6, P<0.05) ; the sputum levels of IL-8 in patients with pulmonary thesaurosis group (914.7±24.3) pg/ml was higher than asthma group and normal group (747.9%±16.8 pg/ml, (405.4±13.7) pg/ml, P<0.05) .
Conclusion:Macrophages and IL-8 may play an important role in the pathogenesis of airway inflammation after long-term inhalation of iron and its compounds, the airway function in patients of occupational pulmonary thesaurosis was found damaged.
