Overview of resistance mechanisms in Campylobacter
10.3760/cma.j.issn.0253-9624.2018.10.021
- VernacularTitle: 弯曲菌耐药机制研究进展
- Author:
Yao BAI
1
;
Shuyao YE
;
Fengqin LI
Author Information
1. Key Laboratory of Food Safety Risk Assessment of Health, China National Center for Food Safety Risk Assessment, Beijing 100021, China
- Publication Type:Review
- Keywords:
Campylobacter;
Drug resistance;
Efflux pump;
Major outer membrane protein
- From:
Chinese Journal of Preventive Medicine
2018;52(10):1072-1077
- CountryChina
- Language:Chinese
-
Abstract:
Campylobacter is a major cause of food-borne gastroenteritis worldwide. While mortality is low when people was infected with Campylobacter, morbidity imparted by post-infectious sequelae such as Guillain-Barré syndrome and irritable bowel syndrome is significantly noteworthy. Although fluoroquinolones and macrolides were the first line drug for the treatment of Campylobacter infections, there is a tough challenge in clinical treatment with high antimicrobial resistant rate and multi antimicrobial resistance arise. Based on the latest literature acquired in this work, we have chosen five classes of antibiotics always used in clinical, and discussed antibiotic resistance mechanisms and transmission of Campylobacter, in order to provide proper therapy both in the veterinary and human populations, and support basis data for the development of new drugs.
