The relationship of maternal and umbilical cord blood zinc level associated with newborn birth weight: a birth cohort study
10.3760/cma.j.issn.0253-9624.2018.10.008
- VernacularTitle: 孕期及脐血血清锌水平与新生儿出生体重关联的队列研究
- Author:
Haiyun XIANG
1
,
2
;
Chunmei LIANG
;
Shuangqin YAN
;
Zhijuan LI
;
Juan LI
;
Kun HUANG
;
Ruiwen TAO
;
Qiufeng ZHANG
;
Jiahu HAO
;
Fangbiao TAO
Author Information
1. Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University
2. Anhui Provincial Laboratory of Population Health and Eugenics, Hefei 230032, China
- Publication Type:Journal Article
- Keywords:
Peripartum period;
Zinc;
Small for gestational age;
Large for gestational age
- From:
Chinese Journal of Preventive Medicine
2018;52(10):1008-1012
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study serum zinc level in pregnancy and umbilical cord blood and their association with newborn birth weight.
Methods:Pregnant women accepting obstetric examination in Ma'anshan Maternal and Child Care Center were recruited from May 2013 to September 2014. The follow up was conducted during their first, second and third trimesters of pregnancy and the self-designed questionnaire was used to collect information of social and demographic characteristics. Blood samples in the first, second pregnancy period and umbilical cord blood samples were collected and serum concentrations of zinc were assayed. 3 239 mother-infant entered the final analysis. We divided serum zinc level into low (<P25), medium (P25-P75) and high (>P75) groups according to their exposure concentrations at each trimesters. Non-conditional multivariate logistic regression model was conducted to evaluate the association between serum zinc level in first, second trimesters of pregnancy and umbilical cord blood with small for gestational age (SGA) and large for gestational age (LGA).
Results:Serum zinc level in P50 (P25-P75) during the first, second trimesters and cord blood were 1 016.18 (907.09-1 145.60), 813.36 (732.47-897.89) and 903.44 (808.71-1 015.64) μg/L, respectively. The prevalence of zinc deficiency during the first, second trimesters and cord blood were 1.5% (44/2 957), 15.9% (492/3 087) and 6.5% (176/2 707), respectively. The prevalence of total SGA and LGA were 9.7% (313/3 239) and 16.5% (536/3 239), respectively. Compared to high-level serum zinc group, the risk of SGA (OR (95%CI) in low-level serum zinc group during first trimesters was 1.51 (1.05-2.19)). Serum zinc level among second pregnancy period and umbilical cord blood had no statistically significant effect on SGA and LGA (both P values >0.05).
Conclusion:Zinc nutritional status of pregnant women in Ma'anshan city was at a good level. The low serum zinc level in first trimester increased the risk of SGA.
