Research progress in therapeutic action of mesenchymal stem cell in allergic rhinitis
10.3760/cma.j.issn.1673-0860.2018.10.015
- VernacularTitle: 间充质干细胞对变应性鼻炎治疗作用的研究进展
- Author:
Xianmei WEI
1
;
Xia GAO
1
;
Chenjie YU
1
Author Information
1. Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Key Medical Discipline, Research Institution of Otorhinolaryngology, Drum Tower Hospital, Nanjing 210008, China
- Publication Type:Review
- Keywords:
Mesenchymal stem cells (MSCs);
Rhinitis, allergic;
Therapy
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2018;53(10):789-793
- CountryChina
- Language:Chinese
-
Abstract:
Allergic rhinitis (AR) is an allergic disease of nasal mucosa, currently the consensus has been reached that there is a Th1/Th2 imbalance in AR′s pathogenesis, meanwhile there are defects in the number and/or function of Treg cells. Mesenchymal stem cells (MSCs) have characteristics of multiple differentiation potential, low immunogenicity and immunomodulation function, which can be migrated and implanted into the nasal inflammatory mucosal, recovering the Th1/Th2 immune balance and up-regulate the Treg cells by immunomodulatory function to improve AR. For the present, the treatment of AR by MSCs is basically at the animal experiment stage. This paper reviews the progress of MSCs in AR′s treatment and provides a basis for the clinical treatment of MSCs.
