Research progress in the pathogenic mechanisms of Porphyromonas gingivalis fimbriae
10.3760/cma.j.issn.1002-0098.2018.10.011
- VernacularTitle: 牙龈卟啉单胞菌菌毛致病机制的研究进展
- Author:
Liuyi DU
1
;
Xiaolin SUN
1
;
Weixian YU
2
;
Jingyi REN
1
;
Xinming GU
1
;
Yanmin ZHOU
1
Author Information
1. Department of Implant Center, School of Stomatology, Jilin University, Changchun 130021, China
2. Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, School of Stomatology, Jilin University, Changchun 130021, China
- Publication Type:Review
- Keywords:
Porphyromonas gingivalis;
Fimbriae, bacterial;
Periodontitis;
Atherosclerosis;
fimA enotyping
- From:
Chinese Journal of Stomatology
2018;53(10):703-707
- CountryChina
- Language:Chinese
-
Abstract:
FimA has been characterized as an important virulence factor for Porphyromonas gingivalis (Pg). These structures play a major role in the mechanisms of adhesion and invasion of Pg to host cells, and can induce cellular activation and cytokines release. FimA can also promote biofilm formation and induce immuno-inflammatory response of host cells. Many studies have characterized FimA to be associated with periodontitis and cardiovascular disease. Pg strains are classified into six types based on divergent nucleotide sequences of the fimA gene (types Ⅰ、Ⅰb、Ⅱ、Ⅲ、Ⅳ andⅤ). The expression of fimbriae is regulated by the fimA gene, which may be the key factor that leads to virulence diversities of Pg, At present, the research on the pathogenesis of FimA mainly focuses on periodontitis and atherosclerosis, which is of great significance for the prevention and treatment of diseases. This paper reviewed the pathogenic effect of FimA in the development of above mentioned two diseases and its application in the prevention.
