Effect of hormone replacement therapy on the uterine structure for patients with myoma of uterus in postmenopause
10.3760/cma.j.issn.1008-6706.2018.09.012
- VernacularTitle: 激素替代治疗对绝经后子宫肌瘤患者的影响分析
- Author:
Yufeng GU
1
Author Information
1. Department of Genecology, Jiaxing Hospital of Zhengjiang Armed Police Hospital, Jiaxing, Zhejiang 314001, China
- Publication Type:Journal Article
- Keywords:
Postmenopause;
Hormone replacement therapy;
Leiomyoma
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(9):1134-1137
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of hormone replacement therapy on the uterine structure for patients with myoma of uterus in postmenopause.
Methods:According to the method of treatment, 149 patients were divided into study group(73 cases) and control group(76 cases). The control group was given oryzanol, while the study group was given hormone replacement threapy (little dose of estradiol combined with dydrogesterone). The sex hormone levels(LH, FSH), uterine structure(volume of uterine fibroids, endometrial thickness, uterine volume) were compared.
Results:The sex hormone levels of LH, FSH in the study group were (12.19±2.39)U/L, (13.14±5.29)U/L, respectively, which were lower than those in the control group[(15.09±3.18)U/L, (22.19±6.25)U/L], the differences were statistically significant (t=11.312, 10.583, all P<0.05). The volume of uterus fibroids, volume of uterine, endometrial thickness in the study group were (6.45±2.21)cm3, (45.56±24.17)cm3, (2.84±1.07)mm, respectively, which in the control group were (5.92±2.31)cm3, (38.25±20.52)cm3, (2.36±0.82)mm, respectively.Compared with the control group, the study group had bigger uterine and endometrial thickness, the differences were statistically significant(t=8.492, 7.954, all P<0.05), while the volume of uterus fibroids had no statistically significant difference between the two groups (t=1.043, P>0.05).
Conclusion:On the uretine structure of patients with myoma of uterus in postmenopause, compared with traditional oryzanol, hormone replacement can improve the status of uretus structure and function, and resist the side-effect of enlargement of the volume of uretus fibroids.There is significant advance for hormone replacement therapy on the uterine structure of patients with uretus fibroids in postmenopause.
