Comparison of the curative effect of metoprolol combined with valsartan and nifedipine controlled release tablets in the treatment of primary hypertension complicated with coronary heart disease
10.3760/cma.j.issn.1008-6706.2018.09.006
- VernacularTitle: 美托洛尔联合缬沙坦与硝苯地平控释片治疗原发性高血压合并冠心病的疗效比较
- Author:
Changrong YI
1
;
Yongping FU
Author Information
1. Department of Cardiovascular Medicine, the Affiliated Hospital of Shaoxing University, Shaoxing, Zhejiang 312000, China
- Publication Type:Journal Article
- Keywords:
Hypertension;
Coronary heart disease;
Metholol;
Valsartan;
Nifedipine controlled release tablets
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(9):1110-1113
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the clinical effect of metoprolol combined with valsartan and nifedipine controlled release tablets in the treatment of primary hypertension complicated with coronary heart disease(CHD).
Methods:200 primary hypertension patients with CHD were selected, and they were randomly divided into observation group and control group according to the digital table, 100 cases in each group.The observation group was treated with metoprolol combined with valsartan, the control group was treated with nifedipine controlled release tablets.The clinical effect of the two groups was compared.
Results:Before treatment, the diastolic and systolic blood pressure of the control group were (106.8±12.3)mmHg and (173.4±22.8)mmHg, respectively, which of the observation group were (104.3±11.4)mmHg, (177.6±24.2)mmHg, respectively, the differences were not statistically significant between the two groups(t=1.265, 0.337, all P>0.05). The diastolic and systolic blood pressure after treatmentin of the observation group were (131.6±17.4)mmHg, (85.3±7.1)mmHg, respectively, and the total effective rate of the observation group was 93.0%(93/100), the improvement rate of angina symptoms of the observation group was 86.0%(86/100), which were significantly better than those of the control group[(131.6±17.4)mmHg, (85.3±7.1) mmHg, 68.0%(68/100), 63.0%(63/100)], the differences were statistically significant (t=5.229, 6.122, χ2=9.148, 7.224, all P<0.05).
Conclusion:The combination of metoprolol and valsartan has better effect in the treatment of primary hypertension complicated with CHD compared with nifedipine controlled release tablets.
