The clinical performance of high risk HPV DNA test among triage women with cytology showing atypical squamous cells of undetermined significance
10.3760/cma.j.issn.0253-9624.2018.09.014
- VernacularTitle: 高危型HPV DNA检测在未明确意义的非典型鳞状上皮细胞分流中的应用效果
- Author:
Shaokai ZHANG
1
;
Dongmei ZHAO
;
Hongmin CHEN
;
Zhen GUO
;
Lingyan REN
;
Manman JIA
;
Jingjuan CHANG
;
Peipei CHEN
;
Shuzheng LIU
;
Xibin SUN
Author Information
1. Office of Henan Cancer Certer, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China
- Publication Type:Journal Article
- Keywords:
Cervical intraepithelial neoplasia;
Human papillomavirus;
Atypical squamous cells of undetermined signification;
Triage
- From:
Chinese Journal of Preventive Medicine
2018;52(9):941-945
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the performance of high risk human papillomavirus (HR-HPV) DNA test for triage ASC-US in Chinese population.
Methods:The study population was from Jiyuan city in Henan Province where a cervical cancer screening cohort (4 026 women) was set up from April to July in 2017. Women with ASC-US and complete recall information of colposcope were selected as the study objects. Self-designed questionnaire was used to survey the general information and medical history of cervical cancer, thencervical cytological speciments were collected for cytodiagnosis and HPV DNA test, followed by colposcopy, lesion biopsy and histology diagnose. The diagnosis of histology was used as the gold standard. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) as well as corresponding 95% confidential interval (CI) were calculated.
Results:The average age of the included 393 women with ASC-US were (50.81±9.22) years old. The positivity of high risk human papillomavirus (HR-HPV), HPV16 and HPV18 were 35.6%, 10.69% and 2.80%, respectively. The sensitivity, specificity, PPV and NPV for HR-HPV to detect CIN2+ were 84.38% (68.25%-93.14%), 68.70% (63.74%-73.26%), 19.29% (13.61%-26.61%) and 98.02% (95.46%-99.15%). When compared with HR-HPV, HPV16/18 had a lower sensitivity (59.38% (42.26%-74.48%)) and a higher specificity(91.14% (87.75%-93.65%)), the PPV and NPV were 59.38% (25.32%-50.98%) and 91.14% (93.61%-97.77%).
Conclusion:It was more effective for HR-HPV to triage ASC-US than HPV16/18. In order to improve the effect of HPV16/18, it should include more HR-HPV types which were more prevalent in Chinese population.
