Advances in research on cell fate determinant Numb regulating liver cancer
10.3760/cma.j.issn.1007-3418.2018.09.019
- VernacularTitle: 细胞命运决定子Numb调控肝癌发生的研究进展
- Author:
Xinrui YANG
1
;
Jie SUN
1
;
Jing WANG
2
;
Yinying LU
1
Author Information
1. Comprehensive Liver Cancer Center, 302 Military Hospital of Chinese Army, Beijing 100039, China
2. Beijing Institute of Basic Medical Sciences, Beijing 100850, China
- Publication Type:Review
- Keywords:
Liver neoplasms;
Cell fate determinant;
Numb
- From:
Chinese Journal of Hepatology
2018;26(9):714-717
- CountryChina
- Language:Chinese
-
Abstract:
Liver cancer is one of the most common malignant tumors in China, ranking fifth in malignant tumors and the third in tumor-related deaths. As a membrane-related protein, the asymmetric distribution of cell fate determinant Numb plays a key role in cell differentiation. Research reports that Numb may be closely associated to the occurrence and development of tumors. Recently, scholars have gradually valued its important role in liver cancer. This article briefly reviews the structure of Numb molecule, relationship between Numb and tumorigenesis, the molecular mechanism of Numb-regulated tumors, and the role of Numb in the development of liver cancer.
