Study on diagnostic value of extracellular volume imaging by magnetic resonance imaging for liver fibrosis of hepatitis B
10.3760/cma.j.issn.1007-3418.2018.09.003
- VernacularTitle: 磁共振成像细胞外容积对乙型肝炎肝纤维化的诊断价值研究
- Author:
Ruofan SHENG
1
,
2
;
Kaipu JIN
1
,
2
;
Heqing WANG
1
,
2
;
Yuan JI
3
;
Caizhong CHEN
1
,
2
;
Mengsu ZENG
1
,
2
Author Information
1. Department of Radiology, Zhongshan Hospital, Fudan University
2. Shanghai Institute of Medical Imaging, Shanghai 200032, China
3. Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
- Publication Type:Journal Article
- Keywords:
Magnetic resonance imaging;
Extracellular matrix;
Liver fibrosis;
Extracellular volume
- From:
Chinese Journal of Hepatology
2018;26(9):650-653
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the diagnostic value of extracellular volume (ECV) imaging by magnetic resonance imaging for liver fibrosis of hepatitis B.
Methods:A retrospective analysis was recruited in patients with chronic hepatitis B, who underwent liver surgery from April to October 2017 for pathological evaluation of liver tissues, and all patients underwent Gd-EOB-DTPA-enhanced T1 mapping to calculate the liver ECV score. The correlation between ECV and staging of hepatic fibrosis and inflammatory activity were compared to clarify the diagnostic value of staging of fibrosis.
Results:66 patients were enrolled in this study. Concerning the staging of liver fibrosis, there were 13, 4, 13, 10, and 26 cases with F0, F1, F2, F3 and F4 stages, respectively. ECV values had high interobserver consistency (correlation coefficient 0.860). The ECV difference between different stages of liver fibrosis was statistically significant (F = 15.02, P < 0.001). There was a significant positive correlation between ECV and fibrosis stage (r = 0.622, P < 0.001), and weak correlation with inflammatory activity (r = 0.332, P = 0.007). Fibrosis staging was an independent factor influencing ECV (P < 0.001). The area under the receiver operator characteristic curve for the diagnosis of liver fibrosis staging F≥1, F≥3 and F4 were 0.760, 0.846 and 0.873, respectively. The diagnostic sensitivity and specificity were 64.15%, 92.31%, 77.78%, 80.00% and 88.46, 72.50%, respectively.
Conclusion:MRI-ECV imaging has great value for staging hepatic fibrosis of hepatitis B, and it can provide an effective method for diagnosis, staging, and evaluating the curative effect of fibrosis.
