Clinical observation of continuous and intermittent application of lamivudine or entecavir resistance mutations in patients with chronic hepatitis B
10.3760/cma.j.issn.1007-3418.2018.09.002
- VernacularTitle: 持续及间断应用拉米夫定或恩替卡韦治疗慢性乙型肝炎出现病毒耐药变异概率的临床观察
- Author:
Shuhong DUAN
1
;
Xiaodong YUAN
;
Xiaoyan LIU
;
Lei WANG
;
Rui BAI
;
Ting PANG
;
Zhongying BAO
Author Information
1. Department of Infection, Beijing Shijitan Hospital of Capital Medical University, Beijing 100038, China
- Publication Type:Journal Article
- Keywords:
Hepatitis B, chronic;
Lamivudine;
Entecavir
- From:
Chinese Journal of Hepatology
2018;26(9):646-649
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe continuous and intermittent application of lamivudine or entecavir resistance mutations in patients with chronic hepatitis B.
Methods:Data of patients with active stage of chronic hepatitis B over the past 6 years were collected and analyzed retrospectively. The incidence of drug resistance mutation and related factors between patients taking LAM or ETV continuously and intermittently were compared with those taking LAM or ETV. Data comparison was performed using χ2 test.
Results:Patients with HBV DNA≥105 copies / ml at the time of initial treatment had higher resistance mutation rates than those with HBV DNA < 105 copies / ml at either continuous or intermittent treatment, and patients with intermittent treatment had higher resistance mutation rates than those with continuous treatment. Simultaneously, the incidence of drug resistance mutation in LAM and ETV in the first, second and third years were significantly higher in intermittent treatment than that of continuous treatment (P < 0.05). There was a positive correlation between the frequency of drug withdrawal and the rate of drug resistance mutation. There were no individual difference and drug difference between LAM and ETV.
Conclusion:In the treatment of chronic hepatitis B with oral nucleoside analogues, drug resistance may occur in either continuous or intermittent treatment. When comparing continuous with intermittent treatment, it suggests that intermittent is more likely to cause viral resistance mutation.
