Progress of large tumor suppressor kinase in tumors
10.3760/cma.j.issn.1006-9801.2018.08.016
- VernacularTitle: 大肿瘤抑制激酶在肿瘤中的研究进展
- Author:
Licong MA
1
,
2
;
Xuyang TIAN
3
;
Yanbin JIA
1
,
2
Author Information
1. School of Basic Medicine and Forensic Medicine, Baotou Medical College, Baotou 014060, China
2. Department of Gastroenterology, the Second Affiliated Hospital of Baotou Medical College, Inner Mongolia Autonomous Region Institute of Digestive Diseases, Baotou 014030, China
3. Department of Gastroenterology, the Second Affiliated Hospital of Baotou Medical College, Inner Mongolia Autonomous Region Institute of Digestive Diseases, Baotou 014030, China
- Publication Type:Review
- Keywords:
Neoplasms;
Large tumor suppressor kinase 1;
Large tumor suppressor kinase 2;
Biological function
- From:
Cancer Research and Clinic
2018;30(8):568-572
- CountryChina
- Language:Chinese
-
Abstract:
Large tumor suppressor kinase 1 (LATS1) and LATS2 are the kinases found in recent years which can inhibit the tumor development. They are highly homologous and overlap in function. LATS1 and LATS2 proteins have been confirmed to be associated with the occurrence of multiple malignancies, including soft tissue sarcoma, leukemia, astrocytoma, breast cancer, prostate cancer, lung cancer, liver cancer, esophageal cancer, etc. Studies have shown that LATS has more extensive biological functions, such as regulating gene transcription and cell cycle checkpoint, inducing apoptosis, inhibiting cell migration, maintaining genetic stability and regulating organ size, and loss of any one can cause a variety of biological changes. So insighting into the structure and mechanism of LATS1 and LATS2 is the key to understanding the occurrence and development of tumors. The discovery of LATS gene and the structure, expression, target and function of LATS protein are summarized in this paper.
