Study on the preoperative clinical criteria for nerve-sparing radical prostatectomy
10.3760/cma.j.issn.1006-9801.2018.08.011
- VernacularTitle: 根治性前列腺切除术选择神经保留的术前临床标准研究
- Author:
Zaisheng ZHU
1
;
Hongqi SHI
2
;
Pengfei ZHOU
1
;
Lizhen XU
1
;
Yibo ZHOU
3
;
Yiyi ZHU
4
;
Jiajun CHEN
4
Author Information
1. Department of Urology, Jinhua Hospital of Zhejiang University, Jinhua 321000, China
2. Department of Pathology, Jinhua Hospital of Zhejiang University, Jinhua 321000, China
3. Department of Ultrasound Imaging, Jinhua Hospital of Zhejiang University, Jinhua 321000, China
4. Graduate School, Zhejiang University School of Medicine, Hangzhou 310058, China
- Publication Type:Journal Article
- Keywords:
Prostate neoplasms;
Radical prostatectomy;
Nerve-sparing
- From:
Cancer Research and Clinic
2018;30(8):553-556,561
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the preoperative clinical criteria for nerve-sparing radical prostatectomy.
Methods:A retrospective analysis of 79 patients undergoing radical prostatectomy with complete clinical and pathological data in Jinhua Hospital of Zhejiang University from January 2012 to December 2016 was performed. The distance between the edge of the prostate tumor and the neurovascular bundle (NVB) was measured. When the distance between the edge of the tumor and the ipsilateral NVB was >2 mm, NVB retention surgery can be performed; when it was ≤2 mm, NVB retention surgery cannot be performed. The influencing factors of the distance between the tumor edge and NVB were analyzed by χ 2 test and logistic regression analysis.
Results:Univariate analysis showed that side-specific positive biopsy core ≥1/3, side-specific maximum tumor length in biopsy core ≥5 mm, side-specific tumor involvement rate in biopsy core ≥1/2 and extraprostatic cancer extension by preoperative magnetic resonance imaging (MRI) examination were associated with the distance between the tumor edge and NVB (all P < 0.01). Multivariate analysis showed that extraprostatic cancer extension by preoperative MRI examination (OR = 3.66, P = 0.006) and side-specific positive biopsy core ≥1/3 (OR = 3.39, P = 0.008) were the independent influence factors.
Conclusion:The clinical criteria for a nerve-sparing radical prostatectomy are side-specific positive biopsy core <1/3 and no extraprostatic extension by preoperative MRI examination.
