Comparative study of microvessel density and lymph node metastasis in papillary thyroid carcinoma with different pathological calcifications
10.3760/cma.j.issn.1006-9801.2018.08.006
- VernacularTitle: 不同病理性钙化类型甲状腺乳头状癌微血管密度及淋巴结转移比较研究
- Author:
Lei WANG
1
;
Hai LI
2
;
Jiayue TANG
1
;
Xiaojie WAN
1
;
Jiajia YANG
1
;
Hong CHENG
3
;
Yanyun SHI
3
;
Tingyue QI
3
;
Jialing DU
4
Author Information
1. Department of Pathology, the Affiliated Hospital of Yangzhou University, Yangzhou 225009, China
2. Department of Pathology, Jiangsu Province Hospital, Nanjing 210029, China
3. Department of Ultrasound, the Affiliated Hospital of Yangzhou University, Yangzhou 225009, China
4. Department of Thyroid and Breast Surgery, the Affiliated Hospital of Yangzhou University, Yangzhou 225009, China
- Publication Type:Journal Article
- Keywords:
Papillary thyroid carcinoma;
Calcification;
Microvascular density;
Lymph node metastasis
- From:
Cancer Research and Clinic
2018;30(8):531-535
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the microvessel density (MVD) and lymph node metastasis in the papillary thyroid carcinoma (PTC) with punctate or sheet calcification.
Methods:Fifty PTC patients in the Affiliated Hospital of Yangzhou University from May 2015 to October 2017 were retrospectively enrolled in this study. All of the 50 PTC patients were divided into punctate calcification group (38 cases) and sheet calcification group (12 cases) according to the different features of pathological calcification in microscope examination. For the two groups, the central and peripheral zone MVD and the lymph node metastasis of each PTC nodule were compared.
Results:For PTC nodules of punctate calcification group, the mean central and peripheral zone MVD were (51±7)/HP and (64±8)/HP, respectively. For those of sheet calcification group, which were (35±5)/HP and (49±6)/HP, respectively. The mean MVD in both central and peripheral zone of PTC nodules of punctate calcification group were significantly higher than those of the sheet calcification group (t values were 10.183 and 12.406, both P < 0.05). The neck Ⅵ area lymph node metastasis rates of the punctate and sheet calcification groups were 42.1% (16/38) and 8.3% (1/12), respectively. The lymph node metastasis rate of the punctate calcification group was significantly higher than that of the sheet calcification group (χ 2 = 4.635, P < 0.05).
Conclusion:PTC nodules with different type of pathological calcification may have different invasion and metastasis, and PTC with punctate calcification is more likely to undergo local metastasis than PTC with sheet calcification.
