Efficacy and safety analysis of VCD and VD regimens for treatment of newly diagnosed patients with multiple myeloma
10.3760/cma.j.issn.1009-9921.2018.08.002
- VernacularTitle: VCD与VD方案治疗初诊多发性骨髓瘤患者效果及安全性分析
- Author:
Liqin ZHANG
1
;
Weiwei TIAN
;
Tao WANG
;
Qiujuan ZHU
;
Rong GONG
;
Ruirui REN
;
Sicheng BIAN
;
Yunxia XIE
;
Yanyan NIU
;
Shaolong HE
;
Lina WANG
;
Jiangxia CUI
;
Jinting AN
;
Liangming MA
Author Information
1. Department of Hematology, Dayi Hospital Affiliated to Shanxi Medical University, Taiyuan 030032, China
- Publication Type:Journal Article
- Keywords:
Multiple myeloma;
Therapy;
Adverse events
- From:
Journal of Leukemia & Lymphoma
2018;27(8):453-458
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the clinical efficacy and safety of bortezomib, cyclophosphamide, dexamethasone (VCD) regimen and bortezomib dexamethasone (VD) regimen in the treatment of the patients with newly diagnosed multiple myeloma (NDMM).
Methods:The clinical data of 73 patients with NDMM in Shanxi Dayi Hospital from January 2013 to January 2016 were retrospectively analyzed. According to the chemotherapy regimen, the patients were divided into VCD group (41 cases) and VD group (32 cases). The efficacy and adverse reactions of the two groups were evaluated.
Results:The overall response rate of VCD group and VD group was 80.5% (33/41) and 78.1% (25/32) respectively, and the difference was not statistically significant (χ 2= 0.061, P= 0.804); and complete remission (CR) rate was 36.6% (15/41) and 15.6% (5/32) respectively, and the difference was statistically significant (χ 2= 3.970, P= 0.046); the median progression-free survival (PFS) was 27 months and 24 months respectively, and the median overall survival (OS) was 35 months and 33 months respectively, and the differences were not statistically significant (all P > 0.05). Most adverse reactions occurred in grade 1-2, in which peripheral polyneuropathy and thrombocytopenia were the most common. Peripheral neuritis was the most common finding among the adverse reactions of grade 3. The incidence of adverse reactions in both groups was not statistically significant (P > 0.05).
Conclusions:VCD and VD regimen could be recommended as a better induction therapy for NDMM patients. Compared with VD scheme, VCD scheme has a higher CR rate.
