Influence of different kinds of ovulation promotion scheme on clinical outcome of patients with IVF-ET/ICSI and POR
10.3760/cma.j.issn.1673-4904.2018.08.003
- VernacularTitle: 不同促排卵方案对行体外受精-胚胎移植/卵胞浆内单精子注射伴卵巢反应低下患者临床结局的影响
- Author:
Ping′an XIONG
;
Xiaoyu LUO
;
Liu YANG
;
Ying LU
;
Runqiang HUANG
;
Zhijun ZHANG
1
Author Information
1. Reproductive Medicine Center, Department of Gynaecology and Obstetrics, Taihe Hospital Affiliated to Hubei Medical College, Hubei Shiyan 442001, China
- Publication Type:Journal Article
- Keywords:
Fertilization in vitro;
Embryo transfer;
Ovulation induction;
routine antagonist scheme
- From:
Chinese Journal of Postgraduates of Medicine
2018;41(8):681-684
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the influence of routine antagonist and optimization super-long termovulation promotion scheme on clinical outcome of patients with IVF-ET/ICSI and POR.
Methods:One hundred and thirty patients with IVF-ET/ICSI and POR were chosen in the period from October 2014 to May 2016 and randomly divided into two groups including control group (65 patients) with routine antagonist scheme and observation group (65 patients) with optimization super-long term scheme for ovulation promotion; and the number and total dose of Gn application, endometrium thickness and P levels in HCG day, the number of ovum retrieved, the incidence of premature LH peak, fertilization rate, quality embryo rate, cycle cancellation rate, implantation rate, clinical pregnancy rate, abortion rate and ectopic pregnancy rate of two groups were compared.
Results:The number and total doses of Gn application of observation group were significant higher than those of control group:(12.50 ± 1.78) d vs.(8.16 ± 1.25) d, (4 272.81 ± 547.95) U vs. (1 909.13 ± 341.48) U (P<0.05). The endometrium thickness and P levels in HCG day of observation group were significant lower than those of control group: (12.86 ± 1.39) mm vs. (10.08 ± 1.02) mm, (0.43 ± 0.17) nmol/L vs. (0.60 ± 0.22) nmol/L (P<0.05). There was no significant difference in the number of ovum retrieved, the incidence of premature LH peak and fertilization rate between two groups (P > 0.05). The quality embryo rate and cycle cancellation rate of observation group was significant lower than that of control group (P<0.05). The implantation rate and clinical pregnancy rate of observation group were significant higher than that of control group (P<0.05).There was no significant difference in the abortion rate and ectopic pregnancy rate between two groups (P > 0.05).
Conclusions:Compared with routine antagonist scheme, optimization super-long termscheme for ovulation promotion in the treatment of patients with IVF-ET/ICSI and POR can efficiently improve the ovulation effects and increase the long-term pregnancy rate, but has the higher overall treatment cost.
