Relationship between 7, 8-dihydrodio1-9.10-epoxide benzoapyrene DNA adducts in peripheral blood of pregnant women and gestational diabetes mellitus
10.3760/cma.j.issn.1673-4904.2018.08.002
- VernacularTitle: 孕妇外周血二氢二醇环氧苯并（a）芘-DNA加合物与妊娠期糖尿病的关系
- Author:
Fang YU
;
Jingjing ZHANG
;
Haiyan HOU
;
Yaqiong CHEN
1
Author Information
1. Department of Gynaecology and Obstetrics, Affiliated Hospital of the Chinese People′s Armed Police Force Logistics College, Tianjin 300162, China
- Publication Type:Journal Article
- Keywords:
Diabetes gestational;
7, 8-dihydrodio1-9.10-epoxide benzo[a]pyrene-DNA adducts;
Air pollution;
Comparative study
- From:
Chinese Journal of Postgraduates of Medicine
2018;41(8):676-680
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To examine the relationship between 7, 8-dihydrodio1-9.10-epoxide benzo[a] pyrene-DNA adducts (BPDE-DNA adducts) in the blood of pregnant women and gestational diabetes mellitus (GDM) and explore the environmental factors of the formation of GDM.
Methods:Forty pregnant women who were diagnosed GDM (case group) and 40 pair-matched normal pregnantwomen who had no complications accordingto age, gravidity, parity and gestational weeks(normal control group) were enrolled in this study. Questionnaire survey was used to obtain personal information, and BPDE-DNA adducts was examined by high performance liquid chromatography. Logistic regression model was used to analyze the relationship between BPDE-DNA adductsand GDM.
Results:The concentration of BPDE-DNA adducts in peripheral blood of case group [(6.1 ± 2.9) adducts/108nucleotides] was significantly higher than that of normal control group [(3.0 ± 1.7) adducts/108nucleotides] (P<0.05). After controlled for possible confounding factors, it was found that maternal serum BPDE-DNA adduct was a risk factor for the occurrence of GDM (OR=1.99, 95%CI 1.43-2.79), while household income was a protective factor (OR=0.55, 95%CI 0.31-0.98). Each increased quartile of the BPDE-DNA adducts exposure level was associated with an elevated risk of GDM by 2.62 folds(OR=3.62, 95%CI 2.07-6.35).
Conclusions:The high level of BPDE-DNA adducts in the peripheral blood of pregnant women is a risk factor for the occurrence of GDM.
