Advances in the research of the application of induced pluripotent stem cells in tissue engineering skin as seed cells

VernacularTitle: 诱导多能干细胞作为种子细胞在组织工程皮肤中的应用研究进展
Author: Shangfeng FU ¹ ; Dewu LIU
Author Information

1. Department of Burns, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China
Publication Type:Review
Keywords: Multipotent stem cells; Wound healing; Tissue engineering skin; Seed cells
From: Chinese Journal of Burns 2018;34(8):569-572
CountryChina
Language:Chinese
Abstract: Tissue engineering skin has a wide application prospect on the clinical treatment of all sorts of skin defect, especially large area burn. The shortage of seed cells and their function improvement are the main problems in this field. The existing seed cells of tissue engineering skin are difficult to meet the needs of clinical application due to the limitations of acquisition, proliferation, and aging. Subsequently, the generation of induced pluripotent stem cells (iPSCs) provides a safe and efficient cell source for tissue engineering skin. Our article focuses on the origin of iPSCs and its characteristics of differentiating into keratinocytes, fibroblasts, melanocytes, vascular smooth muscle cells, nerve cells, and hair follicle, and discusses the main problems and prospects of iPSCs in establishment of tissue engineering skin and application in wound repair.