Two Cases of Heparin-Induced Thrombocytopenia Diagnosed by Particle Gel Immunoassay.
10.3343/kjlm.2006.26.5.334
- Author:
Kyu Sub SONG
1
;
Soon Hee CHANG
;
Jang Soo SUH
Author Information
1. Department of Clinical Pathology, School of Medicine, Kyungpook National University, Daegu, Korea. docsong@hanmail.net
- Publication Type:Case Report
- Keywords:
Heparin-induced thrombocytopenia;
Platelet factor 4-heparin reactive antibody;
Hemodialysis
- MeSH:
Antibodies;
Blood Platelets;
Heparin;
Humans;
Immunoassay*;
Renal Dialysis;
Thrombocytopenia*;
Thrombosis
- From:The Korean Journal of Laboratory Medicine
2006;26(5):334-337
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Heparin-induced thrombocytopenia (HIT) is a serious complication of heparin therapy. It represents initially as thrombocytopenia and is associated with venous or arterial thrombosis. It has been reported that platelet factor 4/heparin complex antibody plays an important role in the pathogenesis of HIT. Patients on hemodialysis have a high risk of developing HIT because heparin is administrated in hemodialysis as anticoagulant. Thrombocytopenia usually occurs 5 to 10 days after the onset of administration, but occasionally, it may occur rapidly in patients who have preformed antibodies from recent heparin use. We report here 2 cases of HIT with platelet factor 4-heparin reactive antibody in hemodialysis patients.
