The challenge of MALDI-TOF MS technique in clinical microbiological diagnosis and application
10.3760/cma.j.issn.1009-9158.2018.08.001
- VernacularTitle: MALDI-TOF MS技术在临床微生物诊断应用中的挑战
- Author:
Yueru TIAN
1
;
Ming GUAN
;
Min LI
Author Information
1. Department of Laboratory Medicine, Shanghai Medical College, Huashan Hospital, Fudan University, Shanghai 200040, China
- Publication Type:Editorial
- Keywords:
Spectrometry, mass, matrix-Assisted laser desorption-ionization;
Microbiological techniques;
Clinical laboratory techniques
- From:
Chinese Journal of Laboratory Medicine
2018;41(8):559-562
- CountryChina
- Language:Chinese
-
Abstract:
MALDI-TOF MS is a revolutionary and innovative technologyin clinical microbiological diagnosis. Due to its advantages of speed, specificity and ease of operation, MALDI-TOF MS has been rapidly accepted and approved by clinical laboratory. However, many challenges appeared when applied in clinical application. For example, sample preparation needs to be further optimized. Identification techniques have limitations. The quality improvement of database and the diversity of microbial species are still under discussion.The application of antimicrobial susceptibility testing is still controversial.The way ofrare identification resultstransmitting into clinical treatment is still being explored. But the application of MALDI-TOF MS in clinical microbiological diagnosis still needs to be improved.(Chin J Lab Med, 2018, 41: 559-562)
