Progress of microglial targeting PET imaging on translocator protein in Parkinson′s disease
10.3760/cma.j.issn.2095-2848.2018.08.010
- VernacularTitle: 基于转位蛋白靶点的PET小胶质细胞显像在帕金森病中的应用进展
- Author:
Weishan ZHANG
1
;
Jun ZHAO
2
;
Chuantao ZUO
1
Author Information
1. PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
2. Department of Nuclear Medicine, East Hospital, Tongji University, Shanghai 200120, China
- Publication Type:Review
- Keywords:
Parkinson disease;
Microglia;
Positron-emission tomography;
Translocator protein;
Trends
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2018;38(8):560-563
- CountryChina
- Language:Chinese
-
Abstract:
Neuroinflammation has been a key pathological process in many neurodegenerative disorders including Parkinson′s disease (PD), while the microglial activation is not only involved in but also regarded as a hallmark of the neuroinflammation. With PET, it has become possible to image in vivo the changes of microglia cells under different pathophysiological conditions. In this review, the basic theory of translocator protein (TSPO)-targeting PET (TSPO-PET) imaging is well described and its intriguing applications in PD are also elaborated.
