Clinical value of adenosine triphosphate stress cerebral blood flow perfusion SPECT imaging in patients with ischemic cerebrovascular disease
10.3760/cma.j.issn.2095-2848.2018.08.001
- VernacularTitle: ATP负荷SPECT脑血流灌注显像对缺血性脑血管病的诊断价值
- Author:
Lijie YIN
1
;
Jue YAN
2
;
Jie LIU
2
;
Rui XU
2
;
Chaoling JIN
2
;
Rongfu WANG
1
Author Information
1. Department of Nuclear Medicine, Peking University First Hospital, Beijing 100034, China
2. Department of Nuclear Medicine, China-Japan Friendship Hospital, Beijing 100029, China
- Publication Type:Clinical Trail
- Keywords:
Brain ischemia;
Tomography, emission-computed, single-photon;
Adenosine triphosphate;
Technetium;
Cysteine
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2018;38(8):521-526
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the value of ATP stress cerebral blood flow perfusion imaging (CBFPI) in diagnosis of ischemic cerebrovascular disease.
Methods:Thirty-two patients with cerebral ischemia and ischemic cerebral infarction (26 males, 6 females, average age: (63.0±8.7) years) in China-Japan Friendship Hospital from November 2016 to February 2017 were enrolled. All subjects underwent 99Tcm-ethylcysteinate dimer (ECD) rest and ATP stress CBFPI. Region of interest (ROI) was drawn in the symmetrical parts of the bilateral frontal lobe, parietal lobe, temporal lobe, occipital lobe and basal ganglia region, and the regional cerebral blood flow (rCBF) was automatically calculated. The images and rCBF of post- and pre-ATP stress CBFPI were analyzed and compared. Paired t test was used for statistical analysis.
Results:The positive rates of rest CBFPI, ATP stress CBFPI, and combination of both imaging were 53.1%(17/32), 65.6%(21/32), and 100%(32/32), respectively. In 16 cases with unilateral vascular stenosis, the average rCBF of diseased hemisphere was lower in stress imaging (62.7±13.3) ml·100 g-1·min-1 than that in rest imaging ((65.8±13.2) ml·100 g-1·min-1; t=3.07, P<0.05). While the average rCBF of the contralateral hemisphere in rest and stress imaging showed no significant difference ((67.4±13.3) vs (65.9±13.0) ml·100 g-1·min-1; t=1.90, P>0.05). In the other 16 patients with bilateral multivessel disease, the average rCBF of whole brain in rest imaging was higher than that in stress imaging: (62.5±13.9) vs (57.5±11.6) ml·100 g-1·min-1; t=3.50, P<0.05. There were 21 out of the 32 patients presented with a decreased cerebrovascular reserve.
Conclusion:ATP stress combined with rest CBFPI may improve positive rate remarkably and help to evaluate the cerebrovascular reserve.
