Clinical research of thrombocytopenia induced by craniospinal irradiation
10.3760/cma.j.issn.1004-4221.2018.08.003
- VernacularTitle: 全中枢照射所致血小板减少的临床研究
- Author:
Henghu FANG
1
;
Qing HAN
;
Xiangfei ZHAO
;
Shanshan WU
;
Zejun LU
;
Jingbo KANG
Author Information
1. Department of Radiation Oncology, Navy General Hospital, Bejing 100048, China
- Publication Type:Journal Article
- Keywords:
Craniospinal irradiation;
Interleukin-11;
Thrombocytopenia/prevention
- From:
Chinese Journal of Radiation Oncology
2018;27(8):727-728
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the clinical efficacy and adverse events of recombinant human interleukin-11(rhIL-11) in the prevention of thrombocytopenia induced by craniospinal irradiation.
Methods:In this randomized control study, 100 patients were randomly divided into A (rhIL-11 group, n=50) and B groups (control group, n=50). In the A group, subcutaneous injection of rhIL-11 was delivered at a dose of 50 μg/kg/d, once daily when the platelet count was< 100×109/L during radiotherapy or decreased by> 50% compared with the baseline level. The administration of rhIL-11 was terminated when the platelet count was ≥ 200×109/L. In the B group, the same protocol was conducted when the platelet count was< 50×109/L and terminated until the platelet count was ≥ 100×109/L. The clinical efficacy was assessed in 92 patients. Subcutaneous injection of rhIL-11 could significantly elevate the minimal platelet count during craniospinal irradiation (P<0.01), considerably shorten the duration of thrombocytopenia (P<0.01) and effectively shorten the duration of radiotherapy (P<0.01). Main adverse events included mild pain at the injection site, sclerosis, redness and fatigue, etc.
Conclusions:Injection of rhIL-11 can significantly enhance the platelet count, effectively reduce the incidence of thrombocytopenia throughout craniospinal irradiation, guarantee the success of radiotherapy and yield mild adverse events.
