Relationship between inflammatory indexes of amniotic fluid and pregnancy outcome of women with cervical incompetence
10.3760/cma.j.issn.0529-567x.2018.08.002
- VernacularTitle: 羊水炎症介质水平与子宫颈机能不全孕妇妊娠结局的关系
- Author:
Yinglin LIU
1
;
Ziya FENG
;
Jianping TAN
;
Liqiong ZHU
;
Jianping ZHANG
Author Information
1. Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China
- Publication Type:Clinical Trail
- Keywords:
Uterine cervical incompetence;
Amniotic fluid;
Cytokines;
Pregnancy outcome;
Cerclage, cervical
- From:
Chinese Journal of Obstetrics and Gynecology
2018;53(8):517-521
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between the level of amniotic fluid inflammatory factor and the pregnancy outcome in patients with cervical incompetence.
Methods:A retrospective case-control study was conducted. Totally 110 cases of pregnant women were diagnosed as cervical incompetence for cervical dilation at the medical examination in Sun Yat-sen Memorial Hospital of Sun Yatsen University, from January 1st, 2015 to December 31th, 2016. A total of 32 patients (29.1%, 32/110) were performed cervical cerclage. According to their neonatal outcomes, they were divided into live infant group (23 cases, 72%) and dead infant group (9 cases, 28%) . The demographic and clinical data of two groups were analyzed and compared.
Results:The mean peripheral blood leucocyte counts, the median amniotic tumor necrosis factor-α (TNF-α) and the median interleukin-8 (IL-8) level of two groups were (10.5±2.8) ×109/L vs (13.6±3.1) ×109/L, 23.80 ng/L (14.9-85.5 ng/L) vs 379.00 ng/L (70.2-418.5 ng/L) , and 3 354 ng/L (1 020-7 500 ng/L) vs 7 500 ng/L (4 210-7 500 ng/L) respectively. The differences were statistically significant (all P<0.05) . The amniotic fluid IL-1β, IL-2 receptor, IL-6, IL-10, C-reactive protein and procalcitonin were not significantly different (all P>0.05) between two groups.
Conclusions:The peripheral blood leucocyte counts, amniotic fluid TNF-α and IL-8 level are the factors affecting the pregnancy outcome in women with cervical incompetence before cervical cerclage. When IL-8 is higher than 3 580 ng/L and TNF-α is higher than 105 ng/L, the death of perinatal infants could be predicted.
