Association between hypothyroidism and sleep breathing disorders in patients with coronary heart disease
10.3760/cma.j.issn.0578-1426.2018.08.007
- VernacularTitle: 冠心病患者甲状腺功能减退与睡眠呼吸障碍的相关性分析
- Author:
Guanqi ZHAO
;
Xiao WANG
;
Jingyao FAN
;
Wei GONG
;
Wen HAO
;
Shenghui ZHOU
;
Aobo LI
;
Ruifeng GUO
;
Han SHI
;
Zexuan LI
;
Shaoping NIE
1
;
Yongxiang WEI
Author Information
1. Emergency & Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Hypothyroidism;
Sleep breathing disorders
- From:
Chinese Journal of Internal Medicine
2018;57(8):571-575
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association between hypothyroidism and sleep breathing disorders in patients with coronary heart disease (CHD).
Methods:A total of 784 patients with CHD were consecutively enrolled at the Emergency & Critical Care Center of Beijing Anzhen Hospital from June 2015 to May 2017. According to thyroid function test results, patients were divided into hypothyroidism group (79 cases) and non-hypothyroidism group (705 cases). All patients had undergone sleep monitoring. The sleep apnea status was compared between the two groups. Multivariate logistic regression and linear regression models were used to analyze the association between hypothyroidism and sleep breathing disorders in patients with CHD.
Results:The proportion of females, mean body weight and body mass index in the hypothyroidism group were higher than those in the non-hypothyroidism group [26.6% vs.16.2%, (78.6±11.6) kg vs. (75.7±12.0) kg, (27.7±3.2) kg/m2 vs. (26.6±3.5) kg/m2, all P<0.05]. Patients in hypothyroidism group had a decreased average oxygen saturation (SaO2) compared with patients in non-hypothyroidism group [ (93.2±2.9) % vs. (93.9±2.0) %, P=0.030]. In addition, events of hypoventilation in hypothyroidism group were significantly higher than those in non-hypothyroidism group[92.5 (45.8, 758.3) times vs. 68.0 (33.0, 125.0) times, P=0.013]. There were no significant differences in apnea hypopnea index, diagnosis of obstructive sleep apnea and other sleep breathing parameters between the two groups (P>0.05). A multiple linear regression analysis found that in patients with CHD, the correlation between hypothyroidism and average sleep SaO2 was significant (β=-0.508, 95%CI -0.989--0.026, P=0.039).
Conclusions:CHD patients with hypothyroidism had a lower sleep average SaO2, and a higher sleep hypopnea events. There is a correlation between hypothyroidism and sleep hypoxia in patients with CHD.
Clinical trial registration:clinicalTrials.gov, NCT03362385.
