Sepsis-associated acute kidney injury: mechanisms and continuous renal replacement therapy
10.3760/cma.j.issn.1673-4912.2018.07.004
- VernacularTitle: 脓毒症相关性肾损伤：发生机制与连续性肾替代治疗
- Author:
Yan ZHU
1
;
Chunxia WANG
;
Yucai ZHANG
Author Information
1. Department of Critical Care Medicine, Shanghai Children′s Hospital, Shanghai Jiaotong University, Shanghai 200062, China
- Publication Type:Journal Article
- Keywords:
Sepsis;
Sepsis-associated acute kidney injury;
Continuous renal replacement therapy;
Children
- From:
Chinese Pediatric Emergency Medicine
2018;25(7):494-497
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is frequently complicated by multiple organ dysfunctional syndrome, and particularly by acute kidney injury.Sepsis-associated acute kidney injury(SAKI)is associated with high risk of hospital mortality and worse disability.The pathophysiological mechanisms for SAKI are still not fully defined.More importance is now increasingly attributed to immunologic and inflammatory mechanisms, along with the activation of the coagulation cascade, triggering adaptive responses of apoptotic cell death and sublethal injury of tubular epithelial cells (TECs)that amplify and potentiate microvascular and endothelial damage.Continuous renal replacement therapy(CRRT)can remove toxins and inflammatory factors, maintain hemodynamics, moderate fluid imbalance.The mode include continuous veno-venous hemofiltration, high volume hemofiltration, continuous veno-venous hemodiafiltration, and etc.But the CRRT timing and dosage need further inquiry.
