Apolipoprotein E Polymorphism in Patients with Ischemic Cerebrovascular Disease.
- Author:
Moon Ho PARK
;
Seong Beom KOH
;
Byung Jo KIM
;
Min Kyu PARK
;
Kun Woo PARK
;
Dae Hie LEE
- Publication Type:Original Article
- MeSH:
Alleles;
Apolipoprotein E2;
Apolipoproteins E;
Apolipoproteins*;
DNA;
Genotype;
Humans;
Lions;
Stroke
- From:Journal of the Korean Geriatrics Society
2001;5(2):151-158
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The possible role of apolipoprotein E (APOE for gene, apoE for protein) allele in atherosclerotic diseases is not clearly understood. For the putative role of APOE genotypes, we examined APOE polymorphism among patients with stroke. METHODS: A total of 202 ischemic stroke patients were involved in this study. The genotype DNA was isolated from whole blood and the APOE alleles were determined by polynicrase chain reaction. RESULTS: The genotype of APOE epsilon3/3 was the most common allele in the stroke group and the control group. The frequencies of APOE epsilon2, epsilon3, epsilon4 allele in stroke group were 0.052, 0.851, and 0.097, respectively. There was no significant difference in APOE genotypes between the stroke group and the control group. No significant associations lions were found for the APOE genotypes and the serum lipid profiles. CONCLUSION: These findings suggest that APOE was not related to the stroke,
