Changes of serum transient receptor potential channel 1 in peripheral blood of patients with vascular depression
10.3760/cma.j.issn.1674-6554.2018.07.009
- VernacularTitle: 血管性抑郁患者血清瞬时受体电位通道1蛋白水平的改变
- Author:
Jingmei ZHONG
1
;
Shaoyuan WU
1
;
Hui CHEN
1
;
Yanqing ZHU
1
;
Wen YANG
1
;
Dandan LI
1
;
Conghua JI
1
;
Xiaojuan LIU
1
Author Information
1. Department of Clinical Psychology, the First People’s Hospital of Yunnan Province, Kunming 650032, China
- Publication Type:Clinical Trail
- Keywords:
Vascular depression;
Major depressive disorder;
Transient receptor potential channel 1
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2018;27(7):623-627
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To understand the changes of serum transient receptor potential channel 1(TRPC1) in patients with vascular depression.
Methods:58 patients with vascular depression, 49 patients with major depressive disorder and 38 healthy controls were recruited.The TRPC1 of all subjects were detected by ELISA.Patients with vascular depression and patients with primary depression were scaled by HAMD-17.The level of TRPC1 was contrasted in different ages groups and in different nosogenesis (cerebral infarction, ischemic cerebrovascular disease, old cerebral hemorrhage, cerebral microbleeds, vascular risk factors, etc.) of vascular depression.The relationship between TRPC1 level and severity of depressive symptoms was further analyzed.
Results:(1)The level of TRPC1 of serum((643.76±118.43)pg/ml) was decreased in patients with vascular depression compared with that in healthy controls ((712.48± 98.75) pg/ml). The level of TRPC1 in patients with vascular depression over 60 years ((601.43±113.55)pg/ml)was lower than that in patients with major depressive disorder over 60 years ((626.32±125.46)pg/ml) and healthy controls over 60 years((721.84± 99.62)pg/ml) .(2) Among the various causes of vascular depression, the level of TRPC1 in patients with cerebral infarction, ischemic cerebrovascular disease and cerebral microbleeds was significantly lower (P<0.05). (3) The levels of TRPC1 in the patients with vascular depression (r=-0.962, P<0.05) and patients with major depressive disorder (r=-0.674, P<0.05) were negatively correlated with HAMD-17 score.
Conclusion:The level of TRPC1 is lower in patients with vascular depression, which is more obvious in patients with cerebral infarction, ischemic cerebrovascular disease, and cerebral microhaemorrhage.The lower the level of TRPC1, the more severe the depression.The neuroprotective effect of TRPC1 is reduced in patients with vascular depression.The TRPC1 can be used as a biomarker for vascular depression.
