The impact of different infarction regions on functional connectivity in motor execution network
10.3760/cma.j.issn.1674-6554.2018.07.007
- VernacularTitle: 脑梗死部位对运动执行网络功能连接的影响
- Author:
Ya WEN
1
;
Jingchun LIU
1
;
Lin JIANG
2
;
Caihong WANG
3
;
Jingliang CHENG
3
;
Chen CAO
4
;
Jun GUO
4
;
Tong HAN
4
;
Xuejun ZHANG
2
Author Information
1. Departments of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China
2. School of Medical Imaging, Tianjin Medical University, Tianjin 300070, China
3. Department of MRI, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
4. Department of Radiology, Tianjin Huanhu Hospital, Tianjin 300350, China
- Publication Type:Clinical Trail
- Keywords:
Cerebral infarction;
Motor execution network;
Functional connectivity;
Resting-state fMRI
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2018;27(7):609-615
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the influence of the location of the infarction lesion on the resting-state functional connectivity (rsFC) of the motor execution network.
Methods:A total of 144 patients with infarction of the motor pathway were involved in the study, including 97 patients with capsule stroke (CS) and 47 patients with pontine stroke (PS).50 age-matched healthy subjects were enrolled.After acquiring the structural images and the resting-state functional MRI data of all the subjects by 3.0-Tesla MR scanner, the functional connectivity was calculated in different regions of interest and the differences of the rsFC within the motor execution network among patients with different infarction location were compared.
Results:Left CS patients exhibited increased rsFC in L_PMd (MNI x, y, z: -22, -13, 57) -R_M1 (MNI x, y, z: 38, -22, 56) (F=3.951, P=0.022), the increased rsFC than healthy controls (P=0.031); Left CS patients exhibited increased rsFC in R_PMv (MNI x, y, z: 53, 0, 25)-L_SPL (MNI x, y, z: -22, -64, 54) than healthy controls (F=4.017, P=0.021), left CS patients exhibited decreased rsFC in R_PCG (MNI x, y, z: 37, -34, 53) -R_PMv (MNI x, y, z: 53, 0, 25) than healthy controls(F=-3.788, P=0.025). Right CS patients exhibited increased rsFC than healthy controls in R_PMd(MNI x, y, z: 28, -10, 54)-L_M1(MNI x, y, z: -38, -22, 56) (F=4.438, P=0.014), right CS patients exhibited increased rsFC than healthy controls in R_PMv(MNI x, y, z: 53, 0, 25)-R_PCG(MNI x, y, z: 37, -34, 53)(F=4.830, P=0.010), right CS patients exhibited decreased rsFC in L_M1(MNI x, y, z: -38, -22, 56)-L_SMA(MNI x, y, z: -5, -4, 57) than healthy controls (F=-5.102, P=0.007). And the left PS patients showed increased rsFC than healthy controls in R_DN -L_SMA (F=4.939, P=0.009), left PS patients exhibited increased rsFC than healthy controls in L_DN-R_SMA (F=3.431, P=0.036), left PS patients exhibited reduced rsFC than healthy controls in R_AICb -R_PMd (F=-4.114, P=0.019). Right PS patients showed increased rsFC compared with healthy controls in L_DN-R_M1(F=3.075, P=0.049), and increased rsFC compared with healthy controls in L_AICb-R_SCb (F=3.725, P=0.027).
Conclusion:The infarction location poses influence on the FC alteration of the motor network after stroke.
