Clinicopathologic features of myxoid adrenocortical adenomas
10.3760/cma.j.issn.0529-5807.2018.07.009
- VernacularTitle: 黏液样肾上腺皮质腺瘤的临床病理学分析
- Author:
Hongmei WU
1
,
2
;
Chao LIU
;
Xunhua LIU
;
Jun YAO
;
Jiqin LIAO
;
Yu CHEN
;
Ping MEI
;
Liyan HUANG
;
Yanhui LIU
Author Information
1. Department of Pathology, Guangdong General Hospital
2. Guangdong Academy of Medical Sciences, Guangzhou 510080, China
- Publication Type:Journal Article
- Keywords:
Adrenal gland neoplasms;
Diagnosis, differential;
Immunohistochemistry
- From:
Chinese Journal of Pathology
2018;47(7):527-530
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the clinicopathologic characteristics, immunophenotype, pathologic diagnosis and differential diagnosis of myxoid adrenocortical adenomas.
Methods:The clinical data, histological features and immunohistochemical results of 4 cases of myxoid adrenocortical adenomas were analyzed, which were collected from January 2014 to December 2016 at Guangdong General Hospital, with review of literature.
Results:Four cases of myxoid adrenocortical adenomas were presented. The patients ages ranged from 26 to 45 years (mean =35 years). Microscopically, it showed a typical morphology, characterized by small-sized tumor cell cords or pseudo-glands embedded in an abundant extracellular myxoid matrix. Immunohistochemical staining showed tumor cells were strongly positive for Melan A, vimentin and focally for α-inhibin, one case showed strong and diffuse positivity for CAM5.2, and two cases showed diffuse positivity for synaptophysin, while negative for CgA, S-100 protein, epithelial antigen, CK7, CK20 and CKpan.
Conclusions:Myxoid adrenocortical adenomas are extremely rare, which may cause confusion with metastatic well-differentiated neuroendocrine tumours, sex cord-stromal tumoursor metanephric adenoma. Recognition of this entity would be beneficial for pathologists to avoid misdiagnosis, and unnecessary treatment.
