The function of exosome-derived miRNAs in gastric cancer

VernacularTitle: 外泌体miRNAs在胃癌中的作用
Author: Mengyao SUN ¹ ; Si CAI ; Jie WANG ; Zhenhua NI ; Qingfeng TANG
Author Information

1. Central Laboratory and Department of Clinical Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China
Publication Type:Journal Article
Keywords: Stomach neoplasms; Exosomes; MicroRNAs; Biomarkers, tumor
From: Chinese Journal of Laboratory Medicine 2018;41(7):499-502
CountryChina
Language:Chinese
Abstract: Gastric cancer, a common malignant tumor in digestive system with high morbidity as well as mortality rate, is insidious at the onset and lack of effective treatments so far. A growing number of studies have shown that exosome-derived miRNAs play an important role in the occurrence and development of gastric cancer. Autocrine exosome miRNAs from gastric cancer cells regulated tumor growth, recurrence, metastasis and drug resistance, etc. Moreover, exosomal miRNAs in the tumor microenvironment can be delivered into cancer cells to facilitate intercellular communication, thus affecting the progress of gastric cancer. Due to exosomes, which were released into circulation from tumor cells, contain abundant, specific and stable miRNAs, exosome-derived miRNAs have a great potential to be used as novel diagnosis biomarkers and treatment targets of gastric cancer.(Chin J Lab Med, 2018, 41: 499-502)