Expressions of PBK and MMP-9 and their effect on concurrent chemoradiotherapy in cervical cancer
10.3760/cma.j.issn.0254-5098.2018.07.009
- VernacularTitle: PBK和基质金属蛋白酶9在宫颈癌中的表达及对同步放化疗疗效的影响
- Author:
Xiaoge SUN
1
;
Yingna BAO
2
;
Hui QIU
1
;
Jing SHI
2
;
Wei ZHANG
2
;
Zhilong YU
2
;
Conghua XIE
1
Author Information
1. Department of Radiotherapy, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
2. Department of Radiotherapy, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China
- Publication Type:Journal Article
- Keywords:
PBK(PDZ binding kinase);
Matrix metalloproteinase 9(MMP-9);
Concurrent chemoradiotherapy;
Cervical cancer
- From:
Chinese Journal of Radiological Medicine and Protection
2018;38(7):529-534
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of DNA damage repair factor PDZ binding kinase (PBK) and matrix metalloproteinase 9 (MMP-9) in cervical cancer and the effect on clinical outcomes of concurrent chemoradiotherapy.
Methods:A total of 65 cervical cancer pathological specimens were collected from January 2014 to July 2016. Immunohistochemistry was used to detect PBK and MMP-9 expression in the specimens.External irrsdeation was treated with intensity-modulated radiation therapy at a dose of 50 Gy/25 F. After 18 times of external irradiation, high-dose rate postoperative treatment was giver at a dose of 30-36 Gy/5-6 F which lasts 3-4 weeks. Weekly chemotherapy with Cisplatin(DDP) begins simultaneously at the beginning of external irradiation. DDP was administered intravenously at a dosage of 40 mg/m2 for 2 to 6 week. All patients were followed-up as routine. The relationship between clinical characteristics and prognosis of patients and the expression of PBK and MMP-9 were analyzed.
Results:PBK was expressed in 92.3% of tissues and MMP-9 was expressed in 69.2% of tissues. The expression of PBK was positively associated with overall survival (OS) and disease progression-free survival (PFS) of cervical cancer patients (χ2=4.324, 8.068, P<0.05). The expression of MMP-9 was related with PFS (χ2=5.134, P<0.05). Patients with PBK and MMP-9 expression suffered poor OS and PFS (χ2=5.382, 9.364, P<0.05).
Conclusions:PBK and MMP-9 could be a biomarker to predict the prognosis of cervical cancer.
