Research progress in OX40/OX40L-induced transplantation tolerance
10.3760/cma.j.issn.0254-5101.2018.07.014
- VernacularTitle: OX40/OX40L在诱导移植免疫耐受中的研究进展
- Author:
Xiaojie CHEN
1
;
Zhijun ZHU
;
Liying SUN
Author Information
1. Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
- Publication Type:Review
- Keywords:
OX40/OX40L;
Organ transplantation;
Immune tolerance
- From:
Chinese Journal of Microbiology and Immunology
2018;38(7):556-558
- CountryChina
- Language:Chinese
-
Abstract:
OX40 (CD134) is a costimulatory molecule on the surface of T cells. It binds to OX40L (CD252) that is expressed on the surface of antigen presenting cells (APC) and participates in the transmission of the second signal of T cell activation, indicating that it is of great importance to the proliferation, differentiation, survival and migration of T cells. In theory, blocking the OX40/OX40L costimulatory pathway can suppress immune response and induce immune tolerance. In this review, we reviewed the research progress in OX40/OX40L-induced transplantation tolerance.
