Research advances in the v-raf murine sarcoma viral oncogene homolog gene mutation in ameloblastoma
10.3760/cma.j.issn.1002-0098.2018.07.016
- VernacularTitle: 丝氨酸/苏氨酸鼠类肉瘤滤过性毒菌致癌同源体B1基因突变在成釉细胞瘤中的研究进展
- Author:
Xiaocui YAN
1
;
Lisha SUN
2
;
Ziwei DONG
1
;
Zhu YOU
2
;
Qing DONG
1
Author Information
1. Department of Pediatric Dentistry, School of Stomatology, North China University of Science and Technology, Tangshan 063000, China
2. Central Laboratory, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China
- Publication Type:Review
- Keywords:
Mouth neoplasms;
Ameloblastoma;
BRAF gene
- From:
Chinese Journal of Stomatology
2018;53(7):500-502
- CountryChina
- Language:Chinese
-
Abstract:
V-raf murine sarcoma viral oncogene homolog B1 (BRAF) is a pro-oncogene, which is one member of the RAF family. Mutated BRAF is found in approximately 8% of human tumors. BRAF gene mutations lead to continuous activation of the mitogen-activatd protein kinase (MAPK) pathway, which resulting in abnormal cell proliferation and tumorigenesis. In recent years, recurrent MAPK signaling mutations were identified in ameloblastoma, among which BRAF-V600E is the most prominent type. This provides new strategies for the targeted treatment of ameloblastoma. This paper reviewed the latest advances in BRAF gene mutation associated with ameloblastoma and its potential clinical significance.
