Change of gene expressions in perirenal adipose tissues of overweight and obese subjects
10.3760/cma.j.issn.1000-6699.2018.07.007
- VernacularTitle: 超重及肥胖人群肾周脂肪组织基因表达的变化
- Author:
Xueqin LI
1
;
Gongcheng WANG
;
Juan LIU
;
Guoxian DING
;
Xiaozheng FANG
Author Information
1. Department of Geratology, the Affiliated Huaian No.1 People′s Hospital of Nanjing Medical University, Huaian 223300, China
- Publication Type:Clinical Trail
- Keywords:
Uncoupling protein 1;
Perirenal adipose tissue;
Subcutaneous adipose tissue;
Obesity
- From:
Chinese Journal of Endocrinology and Metabolism
2018;34(7):567-572
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the change of gene expressions in human perirenal adipose tissue (PAT) and oblique abdomen subcutaneous adipose tissue (SAT) of overweight and obese subjects.
Methods:Ninety-seven patients, including 35 overweight/obese patients and 62 non-obese patients, who underwent renal surgery were included. The clinical data and various gene expressions in PAT and SAT of two groups were analyzed.
Results:Body mass index, waist circumference, systolic blood pressure, resting heart rate, fasting blood glucose, and serum creatinine were significantly higher in overweight/obese patients than those in non-obese patients(P<0.05 or P<0.01). Compared with non-obese patients, PAT adipocytes showed bigger, and the expressions of uncoupling protein-1 (UCP1) mRNA and protein were markedly lower in overweight/obese patients. The mRNA expressions of CIDEA and adiponectin in PAT of overweight/obese patients were significantly lower, while leptin, monocyte chemotactic protein 1, interleukin (IL)-6, and IL-10 mRNA expressions were significantly higher. There were no significant differences in the related gene expressions of SAT between the two groups.
Conclusions:Different parts of adipose tissue reveal various characteristics, and play different roles in the occurrence and development of obesity. UCP1 expression is decreased in PAT of overweight/obese patients, with the changes of adipocytokine expressions. (Chin J Endocrinol Metab, 2018, 34: 567-572)
