Analysis of correlation between serum fatty acid profile and cognitive impairment in the elderly
10.3760/cma.j.issn.0253-9624.2018.06.013
- VernacularTitle: 血清脂肪酸谱与老年认知功能障碍的相关性研究
- Author:
Shuang SONG
;
Hui WANG
;
Shanshan JIA
;
Qingqing MAN
;
Bin QIN
;
Jian ZHANG
1
Author Information
1. National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China
- Publication Type:Journal Article
- Keywords:
Cognition disorders;
Serum;
Cross-sectional studies;
Fatty acid profile
- From:
Chinese Journal of Preventive Medicine
2018;52(6):636-641
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between cognitive impairment and serum fatty acid profile.
Methods:Participants aged ≥60 years were selected from 3 communities in Shijiazhuang in 2015. The questionnaire was performed to collect basic information. And Montreal Cognitive Assessment was applied for the evaluation of cognitive impairment. Blood lipid parameters and serum fatty acid profiles were analyzed for all the subjects. A total of 529 subjects were finally included in this research. Multivariate ordinal logistic model was used to analyze the relationship between serum fatty acid profile and cognitive impairment.
Results:Normal, mild and moderate cognitive impairment accounted for 41.2% (n=218), 51.4% (n=272) and 7.4% (n=39) of all the subjects respectively. With control of age, gender, education, total cholesterol (TC), total triglyceride (TG), low density lipoprotein cholesterol (LDL-C), and high density lipoprotein cholesterol (HDL-C), the OR (95%CI) of eicosenoic acid, nervonic acid and ratio of n-3 and n-6 polyunsaturated fatty acid (n-3/n-6) was 1.06 (1.01-1.10), 0.93 (0.91-0.96), and 0.17 (0.04-0.73).
Conclusion:The risk of cognitive impairment decreased with the raise of serum nervonic acid concentration and n-3/n-6, and increased with the raise of serum eicosenoic acid concentration.
