Incidence trend and change in the age distribution of female breast cancer in cancer registration areas of China from 2000 to 2014
10.3760/cma.j.issn.0253-9624.2018.06.003
- VernacularTitle: 2000—2014年中国肿瘤登记地区女性乳腺癌发病趋势及年龄变化情况分析
- Author:
Kexin SUN
1
;
Rongshou ZHENG
;
Xiuying GU
;
Siwei ZHANG
;
Hongmei ZENG
;
Xiaonong ZOU
;
Changfa XIA
;
Zhixun YANG
;
He LI
;
Wanqing CHEN
;
Jie HE
Author Information
1. Office for Cancer Registry, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Cross-sectional studies;
Age;
Trend;
Aging
- From:
Chinese Journal of Preventive Medicine
2018;52(6):567-572
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To estimate the incidence trend and change in the age distribution of female breast cancer in cancer registry areas in China from 2000 to 2014.
Methods:22 cancer registries in China with continuous monitoring data from 2000 to 2014 were selected. All datasets were checked and evaluated based on data quality control criteria and were included in the analysis. The cancer registries covered 675 954 193 person-years, including 342 010 930 person-years of male and 333 943 263 person-years of female. Female breast cancer cases (International Classification of Diseases-10th Revision: C50) were extracted. Crude incidence rate (CR), age-standardized incidence rate by Chinese standard population(ASIRC), annual percent change (APC), crude and adjusted mean age at onset were calculated. Incidence rates stratified by regions and age groups were calculated.
Results:Female breast cancer incidence rate significantly increased from 31.90/100 000 in 2000 to 63.30/100 000 in 2014. Incidence rate increased rapidly from 2000 to 2008 (CR: APC=6.5%, 95%CI: 5.3%-7.8%; ASIRC: APC=4.6%, 95%CI: 3.6%-5.7%). Its increment slowed down from 2008-2014 (CR: APC=3.2%, 95%CI: 1.4%-5.1%; ASIRC: APC=1.4%, 95%CI:-0.1%-2.9%). The crude mean age at onset increased from 54.4 in 2000 to 57.0 in 2014. Adjusted mean age at onset remained around 54.3 in 2014. Crude mean age at onset increased significantly over time in all registry areas (β=0.192, P<0.001), urban (β=0.205, P<0.001) and rural (β=0.092, P=0.014) areas, while adjusted mean age at onset remained stable in all registry areas (β=0.009, P=0.289), urban (β=0.017, P=0.139) and rural (β=-0.054, P=0.109) areas.
Conclusion:Female breast cancer incidence rate in China increased from 2000 to 2014. Aging of the population resulted in a significant increase in crude mean age at onset. After age adjustment, no significant changes in age distribution were found.
