Dynamic three-dimensional contrast-enhanced ultrasound for treatment assessment of incomplete microwave coagulation on xenograft tumors in nude mice
10.3760/cma.j.issn.1004-4477.2018.06.017
- VernacularTitle: 动态三维超声造影定量分析对裸鼠皮下种植瘤不全微波消融的疗效评估
- Author:
Jiaying CAO
1
;
Feng MAO
;
Peili FAN
;
Wenping WANG
Author Information
1. Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai 200032, China
- Publication Type:Journal Article
- Keywords:
Contrast-enhanced ultrasound, three-dimensional;
Mice;
Microwave;
Ablation techniques
- From:Chinese Journal of Ultrasonography
2018;27(6):529-534
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the feasibility of quantitative analysis of dynamic 3-dimensional contrast-enhanced ultrasound (3D-CEUS) for treatment effects of microwave coagulation on xenograft tumors in nude mice.
Methods:BALB/c nude mice transplanted of HepG2 cells were divided into treatment group(n=16) and control group(n=16). The tumors were treated by incomplete microwave coagulation in the treatment group when their maximum diameters were about 0.8~1.0 cm. The baseline ultrasound and dynamic 3D-CEUS were performed on 1 d before treatment, 3 d after treatment, 7 d after treatment and 14 d after treatment. Time-intensity curves of the tumors were obtained by fitting. The quantitative parameters were also obtained, including peak intensity (PI), time to peak (TTP), mean transit time (MTT), slope (S), area under the curve (AUC), area under the curve of wash-in (AWI), and area under the curve of wash-out (AWO).
Results:There were significant differences(P=0.029) between the two groups in PI, S, AUC, AWO on 3 d and 14 d. The differences in other parameters were not statistically significant (P>0.05). On 1 d before treatment and 7 d after treatment, none of the parameters had statistically significant difference (P>0.05).
Conclusions:The quantitative analysis of dynamic 3D-CEUS is feasible to assess the treatment response on xenograft tumors in nude mice.
