Diagnostic value of BRAF V600E mutation combined with shear wave elastography for thyroid nodule of Bethesda Ⅲ
10.3760/cma.j.issn.1004-4477.2018.06.008
- VernacularTitle: BRAF V600E检测联合剪切波弹性成像对Bethesda Ⅲ类甲状腺结节的诊断价值
- Author:
Jieli LUO
1
;
Kanlun XU
;
Fengbo HUANG
;
Jianshe CHEN
;
Yang SUN
;
Pintong HUANG
Author Information
1. Department of Ultrasonography, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China
- Publication Type:Clinical Trail
- Keywords:
Shear wave elastography;
Thyroid nodule;
Bethesda Ⅲ category;
BRAF V600E
- From:Chinese Journal of Ultrasonography
2018;27(6):496-499
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the diagnostic value of BRAF V600E mutation combined with shear wave elastography(SWE) for thyroid nodules of Bethesda Ⅲ diagnosed by fine-neddle aspiration(FNAC).
Methods:One hundred and seventeen thyroid nodules diagnosed as Bethesda Ⅲ in the department of ultrasound and confirmed by BRAF V600E gene detection, SWE examination and surgery were collected. BRAF V600E detection, SWE examination and both combined with pathological results were using to retrospective analysis.
Results:There were 75 benign nodules and 42 malignant nodules according to pathology. Sensitivity and negative predictive value of BRAF V600E combined with SWE were higher than single BRAF V600E mutation detection and SWE with statistically significant(P=0.01, 0.001; P=0.029, 0.01, respectively). There were no statistically differences between single BRAF V600E mutation detection and SWE for Bethesda Ⅲ nodules(P=0.483, 0.645).
Conclusions:BRAF V600E mutation detection combined with SWE can improve the sensitivity and negative predictive value in the diagnosis of Bethesda Ⅲ thyroid nodules.
