Difference of left ventricular segmental longitudinal strain in patients with lymphoma receiving anthracycline detected by three dimensional speckle tracking imaging
10.3760/cma.j.issn.1004-4477.2018.06.002
- VernacularTitle: 淋巴瘤患者蒽环类药物化疗后左心室纵向应变的节段性差异研究
- Author:
Yuchen XU
1
;
Chujie ZHANG
;
Rui ZHAO
;
Yiyao HE
;
Qunling ZHANG
;
Xianhong SHU
;
Leilei CHENG
Author Information
1. Department of Echocardiography, Shanghai Institute of Medical Imaging & Zhongshan Hospital, Fudan University & Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China
- Publication Type:Clinical Trail
- Keywords:
Echocardiography;
Lymphoma;
Ventricular, left;
Anthracyline;
Three-dimensional speckle tracking imaging
- From:Chinese Journal of Ultrasonography
2018;27(6):467-472
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To detect the changes of systolic function of left ventricle in patients with lymphoma receiving anthracycline by three dimensional speckle tracking imaging(3D-STI).
Methods:Thirty patients with newly diagnosed diffused large B-cell lymphoma who had received R-CHOP chemotherapy were enrolled. Left ventricular global longitudinal strain (GLS), global circumferential strain(GCS) and longitudinal strain(LS) on different left ventricular segments were measured by 3D-STI at baseline, after the completion of 2 cycles and 4 cycles of the regimen respectively.
Results:Compared with baseline, GLS reduced significantly after four cycles of anthracycline chemotherapy(P=0.002). Analysis of LS on different segments of the left ventricle shows: after 2 cycles of anthracycline chemotherapy, LS only on apical septum was significantly decreased(P=0.019). After 4 cycles of treatment, LS on mid anterior, mid anteroseptal, mid inferoseptal, mid anterolateral, apical anterior, apical septal walls and apex worsened (t=3.321, P=0.002; t=2.497, P=0.018; t=2.387, P=0.024; t=2.096, P=0.045; t=4.015, P=0.000; t=4.064, P=0.000; t=3.370, P=0.002, respectively).
Conclusions:LS deterioration emerges on some left ventricular walls in patients with lymphma underwent chemotheapy based on anthracycline in early stage of the remedy, especially on apex and mid segments. LS on apical septum manifests firstly. The segmental LS index maybe expected to be valuable for monitoring of early cardiotoxicity of antharcycline.
