Analysis of preoperative predictive factors and clinical characteristics in patients with parathyroid carcinoma
10.3760/cma.j.issn.0253-3766.2018.06.006
- VernacularTitle: 甲状旁腺癌的临床特征和术前预测因子分析
- Author:
Xiaoai YAO
1
;
Tao JIANG
1
;
Bojun WEI
2
;
Hong CHANG
3
Author Information
1. Department of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
2. Department of Otolaryngology Head and Neck Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
3. Department of Pathologyology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
- Publication Type:Clinical Trail
- Keywords:
Parathyroid carcinoma;
Parathyroid adenoma;
Primary hyperparathyroidism
- From:
Chinese Journal of Oncology
2018;40(6):428-432
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the clinical characteristics and preoperative predictive factors in patients with parathyroid carcinoma.
Methods:From January 2010 to December 2016, 150 patients with pathologically and biochemically confirmed primary hyperparathyroidism were enrolled in this study. The clinical data were reviewed to define 28 cases of parathyroid hyperplasia, 14 cases of parathyroid carcinoma (PC), and 108 cases of parathyroid adenoma (PA). The clinical characteristics between PC and PA group were compared and analyzed to explore predictive factors for PC.
Results:Patients in PC group were significantly younger than those in PA group (47.9±13.9 vs 57.2±14.6 years, P=0.026). The diameter of tumor in PC group was larger than that in PA group (3.6±1.8 vs 2.2±1.4 cm, P=0.005). The levels of albumin-corrected serum calcium, parathyroid hormone (PTH), and alkaline phosphatase (AKP) were all higher in PC group than those in PA group (3.4±0.6 vs 2.9±0.3 mmol/l; 1 157.1 vs 201.6 pg/ml; 168 vs 97 IU/L; all P<0.05). PC correlated with age(r=-0.241, P=0.007), albumin-corrected serum calcium (r=0.324, P<0.001), PTH levels (r=0.301, P=0.001), serum AKP (r=0.217, P=0.019) and tumor size(r=0.238, P=0.011). Receiver operator characteristic curve analysis showed that the optimum cut-off values as follows: albumin-corrected serum calcium 3.15 mmol/L, serum PTH concentration 1 011 pg/ml and tumor diameter 3.35 cm. These indicators can be helpful in the preoperative diagnosis of PC.
Conclusions:Patients with PC were younger than the patients with PA. Albumin-corrected serum calcium, serum PTH concentration, and tumor diameter can be helpful in preoperative diagnosis of PC.
